|The 1st Choice|
|Who to Test?|
The uMMA test was found to have 100% sensitivity (if the person is B12 deficient the test is positive) in identifying less obvious B12 deficient hospital patients. 17,18 (Normal uMMA was less than 5.0 micrograms MMA per milligram creatinine).
Using the uMMA test to screen non-anemic senior populations, 49% of the 35 subjects found to be B12 deficient had a normal serum B12 level. uMMA levels normalized with B12 injections.14 (Normal uMMA was less than 5.0)
Using the uMMA test to screen a vegetarian population (N=54). 43% (23/54) had abnormally high uMMA levels indicating metabolic B12 deficiency. Of those found B12 deficient with the uMMA test, 83% (19/23) had a normal serum B12 level. uMMA levels normalized with adequate B12 therapy.5 (Normal uMMA was less than 4.0)
B12 deficiency is the only know cause for high uMMA except for a rare, life-threatening enzyme deficiency which is evident early in life.
In a screening study, high uMMA levels dropped markedly on all 16 subjects who were treated with vitamin B12 replacement.14
In a study of hospital patients with vitamin B12 deficiency, the uMMA test
A convincing study of the value of the uMMA test showed the reduction of uMMA for vegetarians receiving sublingual B12 ( p<0.01) and nutritional yeast (p<0.05) but not those receiving probiotic food (p>0.2).5 B12 deficiency can developed in 2 years on diet.5