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Dr. Eric Norman
Urinary Phenylacetic Acid Test (uPAA)
Gas Chromatography-Mass Spectrometry (GC-MS) Stable Isotope Dilution Analysis
| The Urinary PKU Test requires only a random, spot urine specimen taken anytime during the day. The uPAA levels are normalized to urine creatinine. This test may have value monitoring PKU patients consuming a phenylalanine-restricted diet recommended for life to prevent intellectual disability and neurologic / psychologic problems. Untreated PKU children often give off a mousy body and urine odor from PAA which is a degradation product of phenylalanine. NCL tested random urine specimens on 32 subjects and found the mean + - standard deviation of uPAA = 4.93 + - 3.2 micromol PAA / mmol creatinine. Previous reported values in normal adults showed uPAA = 4.16 + - 0.91 micromol / mmol creatinine (Am J Clin Nutr 2003; 77(4): 912-918) and for PKU individuals uPAA = 55.6 + - 87.3 micromol / mmol creatinine (Eur J Pediatr 1990; 149(Suppl. 1): 17-24). Levels of uPAA have also been useful in the study of various kinds of mental illnesses such as depression (J Psychiatry Neurosci 1994; 19(4): 282-288). Call 1-800-397-7408 and request our free home test kit or e-mail request to B12tester@aol.com. The cost of the Urinary PKU Test is $150. You may obtain both the Urinary PKU Test and the uMMA test for identifying tissue vitamin B12 deficiency, using the same specimen, for $200. |
For test kit requests or more information
E-Mail NCL
or
Call toll free at 1-800-397-7408
"Not by might, nor by power, but by my Spirit, says the Lord of hosts"
E-Mail NCL
or
Call toll free at 1-800-397-7408
"Not by might, nor by power, but by my Spirit, says the Lord of hosts"